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Association of ABO genetic Polymorphisms and Type 2 Diabetes Mellitus Susceptibility in the Korean Population
Biomed Sci Letters 2024;30:65-72
Published online June 30, 2024;  https://doi.org/10.15616/BSL.2024.30.2.65
© 2024 The Korean Society For Biomedical Laboratory Sciences.

Yu-Na Kim짠,* , Sung Won Lee짠,** and Sangwook Park,**

Department of Biomedical Laboratory Science, College of Health and Biomedical Services, Sangji University, Wonju 26339, Korea
Correspondence to: Sangwook Park. Department of Biomedical Laboratory Science, Sangji University, Rm403 Injae-Gwan, 83 Sangjidae-gil, Wonju-si, Gangwon-do 26339, Korea.
Tel: +82-33-738-7682, Fax: +82-33-738-7652, e-mail: spark367@sangji.ac.kr

*Ungraduate student, **Professor.
These authors contributed equally to this work.
Received March 29, 2024; Revised May 10, 2024; Accepted May 16, 2024.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
 Abstract
The national diabetes and prediabetes prevalence rate has risen among Korean adolescents and adults. Type 2 diabetes mellitus (T2DM) is commonly interrelated with genetic, metabolic, and environmental risk factors in clinical practice. In this study, we analyzed the association between genetic polymorphisms of the ABO gene with T2DM in the Korean population, we conducted an analysis of gene-phenotype correlation, based on an additive genetic model. A total of 8,840 subjects from the Korea Association REsource (KARE) were selected for this study. Using the genetic and epidemiologic data of 754 T2DM cases and 5721 normal controls from the KARE, single nucleotide polymorphisms (SNPs) in the ABO gene were analyzed for their genetic correlation. As a result, 8 SNPs out of the ABO gene demonstrated statistically significant association with T2DM. Among them, rs657152 in the ABO gene statistically showed the most significant correlation with T2DM (P-value=0.0084, OR=1.15, CI=1.04~1.28). The minor allele of A polymorphism within the intron genetic region of ABO directed increased risk of T2DM. This work reveals a significant association between genetic polymorphism in the ABO gene and T2DM. This finding suggested that ABO SNPs markers might be a genetic correlation to the etiology of T2DM.
Keywords : ABO gene, Association, KARE, T2DM