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Replication Study of Genome Wide Association Study of Sleep Duration in Korean Association Resources Cohort
Biomed Sci Letters 2024;30:86-95
Published online June 30, 2024;  https://doi.org/10.15616/BSL.2024.30.2.86
© 2024 The Korean Society For Biomedical Laboratory Sciences.

Seok-Ho Cho1,* , Seon-Ah Kim1,* , Hyun-Seok Jin2,** and Hong Sung Kim1,,**

1Department of Biomedical Laboratory Science, Korea Nazarene University, Cheonan 33172, Korea
2Department of Biomedical Laboratory Science, College of Life and Health Science, Hoseo University, Asan 31499, Korea
Correspondence to: Hong Sung Kim. Department of Biomedical Laboratory Science, Korea Nazarene University, 48 Wolbong-Ro, Seobuk-Gu, Cheonan-City, ChungNam 33172, Korea.
Tel: +82-41-570-4165, Fax: +82-41-570-4258, e-mail: hskim@ kornu.ac.kr

*Ungraduate student, **Professor.
Received May 31, 2024; Revised June 24, 2024; Accepted June 28, 2024.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
 Abstract
Sleep varies from individual to individual and is essential for maintaining good health, making it important for the health of individuals and societies. Sleep duration is influenced by both genetic and environmental factors, and sleep duration has been reported to be associated with obesity, metabolic syndrome, diabetes, and cardiovascular disease. In this study, we identified SNPs associated with sleep duration from the genome-wide association study (GWAS) catalog and compared them with the Korean Association Resource (KARE) cohort to find SNPs associated with sleep duration in Koreans and to identify the genes involved. The results showed that rs1553132, a SNP in the GRM5 gene, was identified as an SNP associated with sleep duration in both the GWAS catalog and the KARE cohort, and rs1504096 was the first SNP found to be associated with sleep duration in Koreans. It was found that having a minor allele tended to increase sleep duration. These results confirm the reproducibility of the association between sleep duration and the GRM5 gene in Koreans and provide a basis for using the associated SNPs as genetic determinants of sleep duration.
Keywords : Sleep duration, GWAS, GRM5 gene, SNP, KARE cohort