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Study on the Stress-relieving Effect of Transdermal Drug Delivery System Using Natural Substances
Biomed Sci Letters 2024;30:317-324
Published online December 31, 2024;  https://doi.org/10.15616/BSL.2024.30.4.317
© 2024 The Korean Society For Biomedical Laboratory Sciences.

Kyung-Yae Hyun1,2,* and Gil-Hyun Lee3,†,*

1Sound-Phonics Institute, Dong-Eui University, Busan 47340, Korea
2Department of Clinical Laboratory Science, Dong-Eui University, Busan 47340, Korea
3Department of Clinical Laboratory Science, Wonkwang Health Science University, Iksan 54538, Korea
Correspondence to: †Gil-Hyun Lee
Department of Clinical Laboratory Science, Wonkwang Health Science University, 514 Iksan-daero, Iksan 54538, Korea
Tel: +82-63-840-1217, Fax: +82-63-840-1219
E-mail: rokmagnum@naver.com
ORCID: https://orcid.org/0000-0002-8757-3359

*Professor.
Received November 28, 2024; Revised December 11, 2024; Accepted December 13, 2024.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
 Abstract
Objectives: This study was conducted to verify the efficacy of the stress transdermal drug delivery system(patch)developed in the previous study.
Methods: A total of 85 people were targeted to confirm the changes in theautonomic nervous system and brain wave index before and after the application of the patch. An electroencephalograph to measure brain wave activity in the frontal lobe and a finger sensor to measure electrocardiogram, heart rate, and arterial oxygen saturation were attached to the patient. After attaching the sensor to a subject who did not have a patch attached, a stabilization period of 5 minutes was allowed and biosignals were collected for approximately 2 minutes.
Results: After applying the patch, the stress index was confirmed to decrease by approximately 31.9% ± 4.2% comparedto before the experiment. After applying the patch, the ratio of alpha waves in the brain wave was found to increase by 9.4% ± 5.3% and the heart rate variability index increased from 8.6 ± 1.3 points to 9.3 ± 1.8.
Conclusion: Considering these research results, it is thought that the patch used in this study has the efficacy ofstabilizing the autonomic nervous system, and is related to the stabilization of brain function accordingly.
Keywords : Stress, Electroencephalogram, Heart rate variability, Autonomic pathways